Ontology highlight
ABSTRACT:
SUBMITTER: Sakano D
PROVIDER: S-EPMC2841049 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Developmental cell 20100301 3
Although the Notch signaling pathway is one of the most intensely studied intracellular signaling pathways, the mechanisms by which Notch signaling regulates transcription remain incompletely understood. Here, we report that B cell leukemia/lymphoma 6 (BCL6), a transcriptional repressor, is a Notch-associated factor. BCL6 is necessary to maintain the expression of Pitx2 in the left lateral plate mesoderm during the patterning of left-right asymmetry in Xenopus embryos. For this process, BCL6 for ...[more]