Ontology highlight
ABSTRACT:
SUBMITTER: Li P
PROVIDER: S-EPMC2841063 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Li Peng P Pashmforoush Mohammad M Sucov Henry M HM
Developmental cell 20100301 3
In many experimental models and clinical examples, defects in the differentiation of the second heart field (SHF) and heart outflow tract septation defects are combined, although the mechanistic basis for this relationship has been unclear. We found that as the initial SHF population incorporates into the outflow tract, it is replenished from the surrounding progenitor territory. In retinoic acid (RA) receptor mutant mice, this latter process fails, and the outflow tract is shortened and misalig ...[more]