Ontology highlight
ABSTRACT:
SUBMITTER: Nakajima M
PROVIDER: S-EPMC2841168 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Nakajima Masahiro M Takahashi Atsushi A Kou Ikuyo I Rodriguez-Fontenla Cristina C Gomez-Reino Juan J JJ Furuichi Tatsuya T Dai Jin J Sudo Akihiro A Uchida Atsumasa A Fukui Naoshi N Kubo Michiaki M Kamatani Naoyuki N Tsunoda Tatsuhiko T Malizos Konstantinos N KN Tsezou Aspasia A Gonzalez Antonio A Nakamura Yusuke Y Ikegawa Shiro S
PloS one 20100318 3
Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of approximately 4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA c ...[more]