Unknown

Dataset Information

0

New sequence variants in HLA class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study.


ABSTRACT: Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of approximately 4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA class II/III genes and their association reached genome-wide significance (combined P = 2.43x10(-8) for rs7775228 and 6.73x10(-8) for rs10947262). Our results suggest that immunologic mechanism is implicated in the etiology of OA.

SUBMITTER: Nakajima M 

PROVIDER: S-EPMC2841168 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature

altmetric image

Publications


Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of approximately 4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA c  ...[more]

Similar Datasets

| S-EPMC6005577 | biostudies-literature
| S-EPMC6081910 | biostudies-literature
| S-EPMC3664012 | biostudies-literature
| S-EPMC5962604 | biostudies-literature
| S-EPMC6308056 | biostudies-literature
| S-EPMC5506002 | biostudies-literature
| S-EPMC3154440 | biostudies-literature
| S-EPMC2858242 | biostudies-literature
| S-EPMC7307371 | biostudies-literature
| S-EPMC5867416 | biostudies-literature