Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma.
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ABSTRACT:
SUBMITTER: Sawai H
PROVIDER: S-EPMC5962604 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma.
Sawai Hiromi H Nishida Nao N Khor Seik-Soon SS Honda Masao M Sugiyama Masaya M Baba Natsumi N Yamada Kayoko K Sawada Norie N Tsugane Shoichiro S Koike Kazuhiko K Kondo Yuji Y Yatsuhashi Hiroshi H Nagaoka Shinya S Taketomi Akinobu A Fukai Moto M Kurosaki Masayuki M Izumi Namiki N Kang Jong-Hon JH Murata Kazumoto K Hino Keisuke K Nishina Sohji S Matsumoto Akihiro A Tanaka Eiji E Sakamoto Naoya N Ogawa Koji K Yamamoto Kazuhide K Tamori Akihiro A Yokosuka Osamu O Kanda Tatsuo T Kanda Tatsuo T Sakaida Isao I Itoh Yoshito Y Eguchi Yuichiro Y Oeda Satoshi S Mochida Satoshi S Yuen Man-Fung MF Seto Wai-Kay WK Poovorawan Yong Y Posuwan Nawarat N Mizokami Masashi M Tokunaga Katsushi K
Scientific reports 20180521 1
We have performed a genome-wide association study (GWAS) including 473 Japanese HBV (hepatitis B virus)-positive HCC (hepatocellular carcinoma) patients and 516 HBV carriers including chronic hepatitis and asymptomatic carrier individuals to identify new host genetic factors associated with HBV-derived HCC in Japanese and other East Asian populations. We identified 65 SNPs with P values < 10<sup>-4</sup> located within the HLA class I region and three SNPs were genotyped in three independent pop ...[more]
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