Ontology highlight
ABSTRACT:
SUBMITTER: Trang P
PROVIDER: S-EPMC2841713 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Trang P P Medina P P PP Wiggins J F JF Ruffino L L Kelnar K K Omotola M M Homer R R Brown D D Bader A G AG Weidhaas J B JB Slack F J FJ
Oncogene 20091207 11
MicroRNAs (miRNAs) have recently emerged as an important new class of cellular regulators that control various cellular processes and are implicated in human diseases, including cancer. Here, we show that loss of let-7 function enhances lung tumor formation in vivo, strongly supporting the hypothesis that let-7 is a tumor suppressor. Moreover, we report that exogenous delivery of let-7 to established tumors in mouse models of non-small-cell lung cancer (NSCLC) significantly reduces the tumor bur ...[more]