Ontology highlight
ABSTRACT:
SUBMITTER: Wiggins PA
PROVIDER: S-EPMC2841910 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Wiggins Paul A PA Cheveralls Keith C KC Martin Joshua S JS Lintner Robert R Kondev Jané J
Proceedings of the National Academy of Sciences of the United States of America 20100301 11
The stochasticity of chromosome organization was investigated by fluorescently labeling genetic loci in live Escherichia coli cells. In spite of the common assumption that the chromosome is well modeled by an unstructured polymer, measurements of the locus distributions reveal that the E. coli chromosome is precisely organized into a nucleoid filament with a linear order. Loci in the body of the nucleoid show a precision of positioning within the cell of better than 10% of the cell length. The p ...[more]