Ontology highlight
ABSTRACT:
SUBMITTER: Chun JN
PROVIDER: S-EPMC2843631 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Chun Jung Nyeo JN Choi Boae B Lee Kyung Wha KW Lee Doo Jae DJ Kang Dong Hoon DH Lee Joo Young JY Song In Sung IS Kim Hye In HI Lee Sang-Hee SH Kim Hyeon Soo HS Lee Na Kyung NK Lee Soo Young SY Lee Kong-Joo KJ Kim Jaesang J Kang Sang Won SW
PloS one 20100323 3
Cytoplasmic presence of Hsp60, which is principally a nuclear gene-encoded mitochondrial chaperonin, has frequently been stated, but its role in intracellular signaling is largely unknown. In this study, we demonstrate that the cytosolic Hsp60 promotes the TNF-alpha-mediated activation of the IKK/NF-kappaB survival pathway via direct interaction with IKKalpha/beta in the cytoplasm. Selective loss or blockade of cytosolic Hsp60 by specific antisense oligonucleotide or neutralizing antibody dimini ...[more]