Ontology highlight
ABSTRACT:
SUBMITTER: Venkatesan B
PROVIDER: S-EPMC3042694 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Venkatesan Balachandar B Valente Anthony J AJ Prabhu Sumanth D SD Shanmugam Prakashsrinivasan P Delafontaine Patrice P Chandrasekar Bysani B
Journal of molecular and cellular cardiology 20100609 4
The transmembrane glycoprotein extracellular matrix metalloproteinase inducer (EMMPRIN), and the pleiotropic proinflammatory cytokine interleukin (IL)-18, play critical roles in myocardial remodeling, by inducing matrix degrading metalloproteinases (MMPs). Previously we showed that IL-18 induces EMMPRIN expression in cardiomyocytes via MyD88/IRAK4/TRAF6/JNK-dependent Sp1 activation. Here in reciprocal studies we demonstrate that EMMPRIN is a potent inducer of IL-18 transcription, protein express ...[more]