Ontology highlight
ABSTRACT:
SUBMITTER: Higham EM
PROVIDER: S-EPMC2843821 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Higham Eileen M EM Wittrup K Dane KD Chen Jianzhu J
Journal of immunology (Baltimore, Md. : 1950) 20100303 7
Tolerogenic dendritic cells in the tumor microenvironment can inhibit the generation and maintenance of robust antitumor T cell responses. In this study, we investigated the effects of local delivery of CD40L by tumor-reactive CD8(+) T cells on dendritic cell activation and antitumor T cell responses in the TRAMP model. To increase the immunostimulatory signal, CD40L was engineered, by deleting the majority of the cytoplasmic domain, to increase its levels of expression and duration on the surfa ...[more]