Ontology highlight
ABSTRACT:
SUBMITTER: Ellett F
PROVIDER: S-EPMC2844499 | biostudies-literature | 2009 Mar-Apr
REPOSITORIES: biostudies-literature
Ellett Felix F Kile Benjamin T BT Lieschke Graham J GJ
Mechanisms of development 20081108 3-4
Erg, a member of the ETS family of transcription factors, has been implicated by previous studies in endothelial and haematopoietic development. Deregulation of the human ERG locus is associated with acute myeloid leukaemia, prostate cancer and Ewing's sarcoma. To better understand the role of Erg during early development, we utilised the zebrafish as a model amenable to descriptive and functional studies in vivo. Zebrafish have a single erg gene that is expressed in mesoderm and its vascular de ...[more]