Ontology highlight
ABSTRACT:
SUBMITTER: Wasmuth EV
PROVIDER: S-EPMC7165421 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Wasmuth Elizabeth V EV Hoover Elizabeth A EA Antar Albert A Klinge Sebastian S Chen Yu Y Sawyers Charles L CL
Proceedings of the National Academy of Sciences of the United States of America 20200327 15
The androgen receptor (AR) is a type I nuclear hormone receptor and the primary drug target in prostate cancer due to its role as a lineage survival factor in prostate luminal epithelium. In prostate cancer, the AR cistrome is reprogrammed relative to normal prostate epithelium and particularly in cancers driven by oncogenic ETS fusion genes. The molecular basis for this change has remained elusive. Using purified proteins, we report a minimal cell-free system that demonstrates interdomain coope ...[more]