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TLR9 polymorphisms are associated with altered IFN-gamma levels in children with cerebral malaria.


ABSTRACT: Toll-like receptor (TLR) polymorphisms have been associated with disease severity in malaria infection, but mechanisms for this association have not been characterized. The TLR2, 4, and 9 single nucleotide polymorphism (SNP) frequencies and serum interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) levels were assessed in Ugandan children with cerebral malaria (CM, N = 65) and uncomplicated malaria (UM, N = 52). The TLR9 C allele at -1237 and G allele at 1174 were strongly linked, and among children with CM, those with the C allele at -1237 or the G allele at 1174 had higher levels of IFN-gamma than those without these alleles (P = 0.03 and 0.008, respectively). The TLR9 SNPs were not associated with altered IFN-gamma levels in children with UM or altered TNF-alpha levels in either group. We present the first human data that TLR SNPs are associated with altered cytokine production in parasitic infection.

SUBMITTER: Sam-Agudu NA 

PROVIDER: S-EPMC2844552 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature

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TLR9 polymorphisms are associated with altered IFN-gamma levels in children with cerebral malaria.

Sam-Agudu Nadia A NA   Greene Jennifer A JA   Opoka Robert O RO   Kazura James W JW   Boivin Michael J MJ   Zimmerman Peter A PA   Riedesel Melissa A MA   Bergemann Tracy L TL   Schimmenti Lisa A LA   John Chandy C CC  

The American journal of tropical medicine and hygiene 20100401 4


Toll-like receptor (TLR) polymorphisms have been associated with disease severity in malaria infection, but mechanisms for this association have not been characterized. The TLR2, 4, and 9 single nucleotide polymorphism (SNP) frequencies and serum interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) levels were assessed in Ugandan children with cerebral malaria (CM, N = 65) and uncomplicated malaria (UM, N = 52). The TLR9 C allele at -1237 and G allele at 1174 were strongly li  ...[more]

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