Ontology highlight
ABSTRACT:
SUBMITTER: Sam-Agudu NA
PROVIDER: S-EPMC2844552 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Sam-Agudu Nadia A NA Greene Jennifer A JA Opoka Robert O RO Kazura James W JW Boivin Michael J MJ Zimmerman Peter A PA Riedesel Melissa A MA Bergemann Tracy L TL Schimmenti Lisa A LA John Chandy C CC
The American journal of tropical medicine and hygiene 20100401 4
Toll-like receptor (TLR) polymorphisms have been associated with disease severity in malaria infection, but mechanisms for this association have not been characterized. The TLR2, 4, and 9 single nucleotide polymorphism (SNP) frequencies and serum interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) levels were assessed in Ugandan children with cerebral malaria (CM, N = 65) and uncomplicated malaria (UM, N = 52). The TLR9 C allele at -1237 and G allele at 1174 were strongly li ...[more]