Ontology highlight
ABSTRACT:
SUBMITTER: Aschrafi A
PROVIDER: S-EPMC2845174 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Aschrafi Armaz A Natera-Naranjo Orlangie O Gioio Anthony E AE Kaplan Barry B BB
Molecular and cellular neurosciences 20100206 4
Trafficking and local translation of axonal mRNAs play a critical role in the development and function of this neuronal subcellular structural domain. In this report, we studied cytochrome c oxidase subunit IV (COXIV) mRNA trafficking into distal axons of primary superior cervical ganglia (SCG) neurons, and provided evidence that axonal trafficking and mitochondrial association of the mRNA are mediated by an element located in a 38bp-long, hairpin-loop forming region within the 3'UTR of the tran ...[more]