Ontology highlight
ABSTRACT:
SUBMITTER: Cai Z
PROVIDER: S-EPMC2845916 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100301 11
FGF signaling is critical in the development of the vertebrate retina, which differentiates in a wave-like pattern similar to that found in the Drosophila eye. In this study, we investigated the mechanism of FGF signaling in vertebrate eye development by identifying Shp2, a protein tyrosine phosphatase, as a novel factor in orchestrating retinal morphogenesis. Using a series of Shp2 conditional mutants, we have shown that Shp2 is specifically required for the initiation of retinal neurogenesis b ...[more]