Ontology highlight
ABSTRACT:
SUBMITTER: Pandey AK
PROVIDER: S-EPMC2845969 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Pandey Amit K AK Raman Sahadevan S Proff Rose R Joshi Swati S Kang Choong-Min CM Rubin Eric J EJ Husson Robert N RN Sassetti Christopher M CM
Tuberculosis (Edinburgh, Scotland) 20080917 1
The ability to ectopically control gene expression is a fundamental tool for the study of bacterial physiology and pathogenesis. While many efficient inducible expression systems are available for Gram-negative bacteria, few are useful in phylogenetically distant organisms, such as mycobacteria. We have adapted a highly-inducible regulon of Rhodococcus rhodochrous to artificially regulate gene expression in both rapidly-growing environmental mycobacteria and slow-growing pathogens, such as Mycob ...[more]