Ontology highlight
ABSTRACT:
SUBMITTER: Sutton MD
PROVIDER: S-EPMC2846234 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Biochimica et biophysica acta 20090621 5
With the discovery that organisms possess multiple DNA polymerases (Pols) displaying different fidelities, processivities, and activities came the realization that mechanisms must exist to manage the actions of these diverse enzymes to prevent gratuitous mutations. Although many of the Pols encoded by most organisms are largely accurate, and participate in DNA replication and DNA repair, a sizeable fraction display a reduced fidelity, and act to catalyze potentially error-prone translesion DNA s ...[more]