Ontology highlight
ABSTRACT:
SUBMITTER: Biswas A
PROVIDER: S-EPMC2846309 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Biswas Arunima A Mani Sridhar S Redinbo Matthew R MR Krasowski Matthew D MD Li Hao H Ekins Sean S
Pharmaceutical research 20090505 8
The pregnane X receptor belongs to the nuclear hormone receptor superfamily and is involved in the transcriptional control of numerous genes. It was originally thought that it was a xenobiotic sensor controlling detoxification pathways. Recent studies have shown an increasingly important role in inflammation and cancer, supporting its function in abrogating tissue damage. PXR orthologs and PXR-like pathways have been identified in several non-mammalian species which corroborate a conserved role ...[more]