Ontology highlight
ABSTRACT:
SUBMITTER: Gronenberg LS
PROVIDER: S-EPMC2846522 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Gronenberg Luisa S LS Kahne Daniel D
Journal of the American Chemical Society 20100301 8
The outer membrane of gram-negative bacteria contains an outer leaflet composed of lipopolysaccharide (LPS) that is transported to this location by a pathway that is essential for viability. It has been suggested that inhibitors of this pathway could be useful antibiotics. Herein we reconstitute the activity of the ATPase component (LptB) of the ABC transporter that initiates LPS transport and assembly. We developed a high-throughput assay and screened a library of kinase inhibitors against LptB ...[more]