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MTOR regulation of autophagy.

ABSTRACT: Nutrient starvation induces autophagy in eukaryotic cells through inhibition of TOR (target of rapamycin), an evolutionarily-conserved protein kinase. TOR, as a central regulator of cell growth, plays a key role at the interface of the pathways that coordinately regulate the balance between cell growth and autophagy in response to nutritional status, growth factor and stress signals. Although TOR has been known as a key regulator of autophagy for more than a decade, the underlying regulatory mechanisms have not been clearly understood. This review discusses the recent advances in understanding of the mechanism by which TOR regulates autophagy with focus on mammalian TOR (mTOR) and its regulation of the autophagy machinery.

SUBMITTER: Jung CH 

PROVIDER: S-EPMC2846630 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature

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mTOR regulation of autophagy.

Jung Chang Hwa CH   Ro Seung-Hyun SH   Cao Jing J   Otto Neil Michael NM   Kim Do-Hyung DH  

FEBS letters 20100118 7

Nutrient starvation induces autophagy in eukaryotic cells through inhibition of TOR (target of rapamycin), an evolutionarily-conserved protein kinase. TOR, as a central regulator of cell growth, plays a key role at the interface of the pathways that coordinately regulate the balance between cell growth and autophagy in response to nutritional status, growth factor and stress signals. Although TOR has been known as a key regulator of autophagy for more than a decade, the underlying regulatory mec  ...[more]