MTOR: a pharmacologic target for autophagy regulation.
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ABSTRACT:
SUBMITTER: Kim YC
PROVIDER: S-EPMC4382265 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Publications
mTOR: a pharmacologic target for autophagy regulation.
Kim Young Chul YC Guan Kun-Liang KL
The Journal of clinical investigation 20150102 1
mTOR, a serine/threonine kinase, is a master regulator of cellular metabolism. mTOR regulates cell growth and proliferation in response to a wide range of cues, and its signaling pathway is deregulated in many human diseases. mTOR also plays a crucial role in regulating autophagy. This Review provides an overview of the mTOR signaling pathway, the mechanisms of mTOR in autophagy regulation, and the clinical implications of mTOR inhibitors in disease treatment. ...[more]
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