Ontology highlight
ABSTRACT:
SUBMITTER: Kortylewski M
PROVIDER: S-EPMC2846721 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Kortylewski Marcin M Swiderski Piotr P Herrmann Andreas A Wang Lin L Kowolik Claudia C Kujawski Maciej M Lee Heehyoung H Scuto Anna A Liu Yong Y Yang Chunmei C Deng Jiehui J Soifer Harris S HS Raubitschek Andrew A Forman Stephen S Rossi John J JJ Pardoll Drew M DM Jove Richard R Yu Hua H
Nature biotechnology 20090913 10
Efficient delivery of small interfering (si)RNA to specific cell populations in vivo remains a formidable challenge to its successful therapeutic application. We show that siRNA synthetically linked to a CpG oligonucleotide agonist of toll-like receptor (TLR)9 targets and silences genes in TLR9(+) myeloid cells and B cells, both of which are key components of the tumor microenvironment. When a CpG-conjugated siRNA that targets the immune suppressor gene Stat3 is injected in mice either locally a ...[more]