Ontology highlight
ABSTRACT:
SUBMITTER: Jiang X
PROVIDER: S-EPMC6888973 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Jiang Xiaodong X Muthusamy Viswanathan V Fedorova Olga O Kong Yong Y Kim Daniel J DJ Bosenberg Marcus M Pyle Anna Marie AM Iwasaki Akiko A
The Journal of experimental medicine 20191010 12
Cytosolic nucleic acid-sensing pathways can be triggered to enhance immune response to cancer. In this study, we tested the antitumor activity of a unique RIG-I agonist, stem loop RNA (SLR) 14. In the immunogenic tumor models, we observed significant tumor growth delay and an extended survival in SLR14-treated mice. SLR14 also greatly improved antitumor efficacy of anti-PD1 antibody over single-agent treatment. SLR14 was mainly taken up by CD11b<sup>+</sup> myeloid cells in the tumor microenviro ...[more]