Synaptic correlates of fear extinction in the amygdala.
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ABSTRACT:
SUBMITTER: Amano T
PROVIDER: S-EPMC2847017 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Publications
Synaptic correlates of fear extinction in the amygdala.
Amano Taiju T Unal Cagri T CT Paré Denis D
Nature neuroscience 20100307 4
Anxiety disorders such as post-traumatic stress are characterized by an impaired ability to learn that cues previously associated with danger no longer represent a threat. However, the mechanisms underlying fear extinction remain unclear. We found that fear extinction in rats was associated with increased levels of synaptic inhibition in fear output neurons of the central amygdala (CEA). This increased inhibition resulted from a potentiation of fear input synapses to GABAergic intercalated amygd ...[more]
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