Ontology highlight
ABSTRACT:
SUBMITTER: Whittle N
PROVIDER: S-EPMC8260764 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Whittle Nigel N Fadok Jonathan J MacPherson Kathryn P KP Nguyen Robin R Botta Paolo P Wolff Steffen B E SBE Müller Christian C Herry Cyril C Tovote Philip P Holmes Andrew A Singewald Nicolas N Lüthi Andreas A Ciocchi Stéphane S
Nature communications 20210706 1
Fear extinction is an adaptive process whereby defensive responses are attenuated following repeated experience of prior fear-related stimuli without harm. The formation of extinction memories involves interactions between various corticolimbic structures, resulting in reduced central amygdala (CEA) output. Recent studies show, however, the CEA is not merely an output relay of fear responses but contains multiple neuronal subpopulations that interact to calibrate levels of fear responding. Here, ...[more]