Ontology highlight
ABSTRACT:
SUBMITTER: Lavens D
PROVIDER: S-EPMC2847223 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Lavens Delphine D Peelman Frank F Van der Heyden José J Uyttendaele Isabel I Catteeuw Dominiek D Verhee Annick A Van Schoubroeck Bertrand B Kurth Julia J Hallenberger Sabine S Clayton Reginald R Tavernier Jan J
Nucleic acids research 20091216 6
The host restriction factor Apobec3G is a cytidine deaminase that incorporates into HIV-1 virions and interferes with viral replication. The HIV-1 accessory protein Vif subverts Apobec3G by targeting it for proteasomal degradation. We propose a model in which Apobec3G N-terminal domains symmetrically interact via a head-to-head interface containing residues 122 RLYYFW 127. To validate this model and to characterize the Apobec3G-Apobec3G and the Apobec3G-Vif interactions, the mammalian protein-pr ...[more]