Multiple common variants for celiac disease influencing immune gene expression.
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ABSTRACT:
SUBMITTER: Dubois PC
PROVIDER: S-EPMC2847618 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Publications
Multiple common variants for celiac disease influencing immune gene expression.
Dubois Patrick C A PC Trynka Gosia G Franke Lude L Hunt Karen A KA Romanos Jihane J Curtotti Alessandra A Zhernakova Alexandra A Heap Graham A R GA Adány Róza R Aromaa Arpo A Bardella Maria Teresa MT van den Berg Leonard H LH Bockett Nicholas A NA de la Concha Emilio G EG Dema Bárbara B Fehrmann Rudolf S N RS Fernández-Arquero Miguel M Fiatal Szilvia S Grandone Elvira E Green Peter M PM Groen Harry J M HJ Gwilliam Rhian R Houwen Roderick H J RH Hunt Sarah E SE Kaukinen Katri K Kelleher Dermot D Korponay-Szabo Ilma I Kurppa Kalle K MacMathuna Padraic P Mäki Markku M Mazzilli Maria Cristina MC McCann Owen T OT Mearin M Luisa ML Mein Charles A CA Mirza Muddassar M MM Mistry Vanisha V Mora Barbara B Morley Katherine I KI Mulder Chris J CJ Murray Joseph A JA Núñez Concepción C Oosterom Elvira E Ophoff Roel A RA Polanco Isabel I Peltonen Leena L Platteel Mathieu M Rybak Anna A Salomaa Veikko V Schweizer Joachim J JJ Sperandeo Maria Pia MP Tack Greetje J GJ Turner Graham G Veldink Jan H JH Verbeek Wieke H M WH Weersma Rinse K RK Wolters Victorien M VM Urcelay Elena E Cukrowska Bozena B Greco Luigi L Neuhausen Susan L SL McManus Ross R Barisani Donatella D Deloukas Panos P Barrett Jeffrey C JC Saavalainen Paivi P Wijmenga Cisca C van Heel David A DA
Nature genetics 20100228 4
We performed a second-generation genome-wide association study of 4,533 individuals with celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs with P(GWAS) < 10(-4) and 18 SNPs from 14 known loci in a further 4,918 cases and 5,684 controls. Variants from 13 new regions reached genome-wide significance (P(combined) < 5 x 10(-8)); most contain genes with immune functions (BACH2, CCR4, CD80, CIITA-SOCS1-CLEC16A, ICOSLG and ZMIZ1), with ETS1, RUNX3, THEMIS and TNFRSF14 h ...[more]
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