Newly identified genetic risk variants for celiac disease related to the immune response.
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ABSTRACT:
SUBMITTER: Hunt KA
PROVIDER: S-EPMC2673512 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Publications
Newly identified genetic risk variants for celiac disease related to the immune response.
Hunt Karen A KA Zhernakova Alexandra A Turner Graham G Heap Graham A R GA Franke Lude L Bruinenberg Marcel M Romanos Jihane J Dinesen Lotte C LC Ryan Anthony W AW Panesar Davinder D Gwilliam Rhian R Takeuchi Fumihiko F McLaren William M WM Holmes Geoffrey K T GK Howdle Peter D PD Walters Julian R F JR Sanders David S DS Playford Raymond J RJ Trynka Gosia G Mulder Chris J J CJ Mearin M Luisa ML Verbeek Wieke H M WH Trimble Valerie V Stevens Fiona M FM O'Morain Colm C Kennedy Nicholas P NP Kelleher Dermot D Pennington Daniel J DJ Strachan David P DP McArdle Wendy L WL Mein Charles A CA Wapenaar Martin C MC Deloukas Panos P McGinnis Ralph R McManus Ross R Wijmenga Cisca C van Heel David A DA
Nature genetics 20080302 4
Our genome-wide association study of celiac disease previously identified risk variants in the IL2-IL21 region. To identify additional risk variants, we genotyped 1,020 of the most strongly associated non-HLA markers in an additional 1,643 cases and 3,406 controls. Through joint analysis including the genome-wide association study data (767 cases, 1,422 controls), we identified seven previously unknown risk regions (P < 5 x 10(-7)). Six regions harbor genes controlling immune responses, includin ...[more]
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