Ontology highlight
ABSTRACT:
SUBMITTER: Jindal AK
PROVIDER: S-EPMC2848490 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Jindal Ashish K AK Merritt Matthew E ME Suh Eul Hyun EH Malloy Craig R CR Sherry A Dean AD Kovács Zoltán Z
Journal of the American Chemical Society 20100201 6
Hyperpolarization can increase the sensitivity of NMR/MRI experiments, but the primary limitation is the T(1) decay of magnetization. Due to its long T(1), the hyperpolarized (89)Y nucleus makes an excellent candidate as an in vivo spectroscopy/imaging probe. Here we report the (89)Y chemical shift dependence upon pH for two hyperpolarized (89)Y(III) complexes and demonstrate how such complexes can be used as sensitive spectroscopy/imaging agents to measure pH. ...[more]