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Hyperpolarized 89Y complexes as pH sensitive NMR probes.

ABSTRACT: Hyperpolarization can increase the sensitivity of NMR/MRI experiments, but the primary limitation is the T(1) decay of magnetization. Due to its long T(1), the hyperpolarized (89)Y nucleus makes an excellent candidate as an in vivo spectroscopy/imaging probe. Here we report the (89)Y chemical shift dependence upon pH for two hyperpolarized (89)Y(III) complexes and demonstrate how such complexes can be used as sensitive spectroscopy/imaging agents to measure pH.

SUBMITTER: Jindal AK

PROVIDER: S-EPMC2848490 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature

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Hyperpolarized 89Y complexes as pH sensitive NMR probes.

Jindal Ashish K AK Merritt Matthew E ME Suh Eul Hyun EH Malloy Craig R CR Sherry A Dean AD Kovács Zoltán Z

Journal of the American Chemical Society 20100201 6

Hyperpolarization can increase the sensitivity of NMR/MRI experiments, but the primary limitation is the T(1) decay of magnetization. Due to its long T(1), the hyperpolarized (89)Y nucleus makes an excellent candidate as an in vivo spectroscopy/imaging probe. Here we report the (89)Y chemical shift dependence upon pH for two hyperpolarized (89)Y(III) complexes and demonstrate how such complexes can be used as sensitive spectroscopy/imaging agents to measure pH. ...[more]

PMID: 20102196

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