Ontology highlight
ABSTRACT:
SUBMITTER: Gamba L
PROVIDER: S-EPMC2851976 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Gamba Laurent L Cubedo Nicolas N Ghysen Alain A Lutfalla Georges G Dambly-Chaudière Christine C
Proceedings of the National Academy of Sciences of the United States of America 20100322 14
The primordium that generates the embryonic posterior lateral line of zebrafish migrates from the head to the tip of the tail along a trail of SDF1-producing cells. This migration critically depends on the presence of the SDF1 receptor CXCR4 in the leading region of the primordium and on the presence of a second SDF1 receptor, CXCR7, in the trailing region of the primordium. Here we show that inactivation of the estrogen receptor ESR1 results in ectopic expression of cxcr4b throughout the primor ...[more]