Ontology highlight
ABSTRACT:
SUBMITTER: Knutsdottir H
PROVIDER: S-EPMC5393887 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
PLoS computational biology 20170403 4
Collective cell migration plays an important role in development. Here, we study the posterior lateral line primordium (PLLP) a group of about 100 cells, destined to form sensory structures, that migrates from head to tail in the zebrafish embryo. We model mutually inhibitory FGF-Wnt signalling network in the PLLP and link tissue subdivision (Wnt receptor and FGF receptor activity domains) to receptor-ligand parameters. We then use a 3D cell-based simulation with realistic cell-cell adhesion, in ...[more]