Ontology highlight
ABSTRACT:
SUBMITTER: McCoy AJ
PROVIDER: S-EPMC2852310 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
McCoy Airlie J AJ Read Randy J RJ
Acta crystallographica. Section D, Biological crystallography 20100324 Pt 4
Developments in protein crystal structure determination by experimental phasing are reviewed, emphasizing the theoretical continuum between experimental phasing, density modification, model building and refinement. Traditional notions of the composition of the substructure and the best coefficients for map generation are discussed. Pitfalls such as determining the enantiomorph, identifying centrosymmetry (or pseudo-symmetry) in the substructure and crystal twinning are discussed in detail. An ap ...[more]