Ontology highlight
ABSTRACT:
SUBMITTER: Loiarro M
PROVIDER: S-EPMC2852602 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Loiarro Maria M Ruggiero Vito V Sette Claudio C
Mediators of inflammation 20100408
The members of Toll-like receptor/interleukin (IL)-1 receptor (TLR/IL-1R) superfamily play a fundamental role in the immune response. These receptors detect microbial components and trigger complex signalling pathways that result in increased expression of multiple inflammatory genes. On the other hand, an aberrant activation of TLR/IL-1R signalling can promote the onset of inflammatory and autoimmune diseases, raising the interest in the development of therapeutic strategies for the control of ...[more]