Ontology highlight
ABSTRACT:
SUBMITTER: Lin SC
PROVIDER: S-EPMC2888693 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Lin Su-Chang SC Lo Yu-Chih YC Wu Hao H
Nature 20100519 7300
MyD88, IRAK4 and IRAK2 are critical signalling mediators of the TLR/IL1-R superfamily. Here we report the crystal structure of the MyD88-IRAK4-IRAK2 death domain (DD) complex, which surprisingly reveals a left-handed helical oligomer that consists of 6 MyD88, 4 IRAK4 and 4 IRAK2 DDs. Assembly of this helical signalling tower is hierarchical, in which MyD88 recruits IRAK4 and the MyD88-IRAK4 complex recruits the IRAK4 substrates IRAK2 or the related IRAK1. Formation of these Myddosome complexes b ...[more]