Ontology highlight
ABSTRACT:
SUBMITTER: Cizas P
PROVIDER: S-EPMC2853175 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Cizas Paulius P Budvytyte Rima R Morkuniene Ramune R Moldovan Radu R Broccio Matteo M Lösche Mathias M Niaura Gediminas G Valincius Gintaras G Borutaite Vilmante V
Archives of biochemistry and biophysics 20100211 2
The link between the size of soluble amyloid beta (Abeta) oligomers and their toxicity to rat cerebellar granule cells (CGC) was investigated. Variation in conditions during in vitro oligomerization of Abeta(1-42) resulted in peptide assemblies with different particle size as measured by atomic force microscopy and confirmed by dynamic light scattering and fluorescence correlation spectroscopy. Small oligomers of Abeta(1-42) with a mean particle z-height of 1-2 nm exhibited propensity to bind to ...[more]