Ontology highlight
ABSTRACT:
SUBMITTER: Stroud JC
PROVIDER: S-EPMC3356606 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Stroud James C JC Liu Cong C Teng Poh K PK Eisenberg David D
Proceedings of the National Academy of Sciences of the United States of America 20120430 20
Although amyloid fibers are found in neurodegenerative diseases, evidence points to soluble oligomers of amyloid-forming proteins as the cytotoxic species. Here, we establish that our preparation of toxic amyloid-β(1-42) (Abeta42) fibrillar oligomers (TABFOs) shares with mature amyloid fibrils the cross-β structure, in which adjacent β-sheets adhere by interpenetration of protein side chains. We study the structure and properties of TABFOs by powder X-ray diffraction, EM, circular dichroism, FTI ...[more]