Ontology highlight
ABSTRACT:
SUBMITTER: Murai S
PROVIDER: S-EPMC2854205 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Murai Shin S Stein Paula P Buffone Mariano G MG Yamashita Shigeru S Schultz Richard M RM
Developmental biology 20100226 1
Mouse oocytes acquire the ability to replicate DNA during meiotic maturation, presumably to ensure that DNA replication does not occur precociously between MI and MII and only after fertilization. Acquisition of DNA replication competence requires protein synthesis, but the identity of the proteins required for DNA replication is poorly described. In Xenopus, the only component missing for DNA replication competence is CDC6, which is synthesized from a dormant maternal mRNA recruited during oocy ...[more]