Ontology highlight
ABSTRACT:
SUBMITTER: Cohen MA
PROVIDER: S-EPMC2854325 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Cohen Malkiel A MA Itsykson Pavel P Reubinoff Benjamin E BE
Developmental biology 20100210 2
The mechanisms that govern human neural specification are not completely characterized. Here we used human embryonic stem cells (hESCs) to study the role of fibroblast growth factor (FGF)-signaling in early human neural specification. Differentiation was obtained by culturing clusters of hESCs in chemically-defined medium. We show that FGF-signaling, which is endogenously active during early differentiation of hESCs, induces early neural specification, while its blockage inhibits neuralization. ...[more]