Ontology highlight
ABSTRACT:
SUBMITTER: LaVaute TM
PROVIDER: S-EPMC2789116 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Stem cells (Dayton, Ohio) 20090801 8
Inhibition of bone morphogenetic protein (BMP) signaling is required for vertebrate neural induction, and fibroblast growth factors (FGFs) may affect neural induction through phosphorylation at the linker region of Smad1, thus regulating BMP signaling. Here we show that human embryonic stem cells efficiently convert to neuroepithelial cells in the absence of BMP antagonists, or even when exposed to high concentrations of exogenous BMP4. Molecular and functional analyses revealed multiple levels ...[more]