Ontology highlight
ABSTRACT:
SUBMITTER: Greig KT
PROVIDER: S-EPMC2854426 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Greig Kylie T KT de Graaf Carolyn A CA Murphy James M JM Carpinelli Marina R MR Pang Swee Heng Milon SH Frampton Jon J Kile Benjamin T BT Hilton Douglas J DJ Nutt Stephen L SL
Blood 20100203 14
c-Myb is a transcription factor with functions in many hematopoietic lineages. c-Myb-deficient mice display reduced numbers of B cells; however, it is unknown what role c-Myb plays in B lymphopoiesis because no critical target genes have been identified in the B-cell lineage. We demonstrate that conditional deletion of c-Myb in B-cell progenitors completely abolishes B-cell development. c-Myb is required for lymphoid progenitors to respond to the cytokines interleukin-7 and thymic stromal lympho ...[more]