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SUMO-specific protease 1 is critical for early lymphoid development through regulation of STAT5 activation.

ABSTRACT: Small ubiquitin-like modifier (SUMO) modification has emerged as an important regulatory mechanism during embryonic development. However, it is not known whether SUMOylation plays a role in the development of the immune system. Here, we show that SUMO-specific protease 1 (SENP1) is essential for the development of early T and B cells. STAT5, a key regulator of lymphoid development, is modified by SUMO-2 and is specifically regulated by SENP1. In the absence of SENP1, SUMO-2 modified STAT5 accumulates in early lymphoid precursors, resulting in a block in its acetylation and subsequent signaling. These results demonstrate a crucial role of SENP1 in the regulation of STAT5 activation during early lymphoid development.

SUBMITTER: Van Nguyen T

PROVIDER: S-EPMC3269036 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature

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SUMO-specific protease 1 is critical for early lymphoid development through regulation of STAT5 activation.

Van Nguyen Thang T Angkasekwinai Pornpimon P Dou Hong H Lin Feng-Ming FM Lu Long-Sheng LS Cheng Jinke J Chin Y Eugene YE Dong Chen C Yeh Edward T H ET

Molecular cell 20120101 2

Small ubiquitin-like modifier (SUMO) modification has emerged as an important regulatory mechanism during embryonic development. However, it is not known whether SUMOylation plays a role in the development of the immune system. Here, we show that SUMO-specific protease 1 (SENP1) is essential for the development of early T and B cells. STAT5, a key regulator of lymphoid development, is modified by SUMO-2 and is specifically regulated by SENP1. In the absence of SENP1, SUMO-2 modified STAT5 accumu ...[more]

PMID: 22284677

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