Ontology highlight
ABSTRACT:
SUBMITTER: Yu Z
PROVIDER: S-EPMC2855538 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Yu Zhiguo Z Smanski Michael J MJ Peterson Ryan M RM Marchillo Karen K Andes David D Rajski Scott R SR Shen Ben B
Organic letters 20100401 8
Platensimycin (1) and platencin (2) are novel antibiotic leads against multidrug resistant pathogens. The production of 2 in Streptomyces platensis MA7339 is under the control of ptnR1, a GntR-like transcriptional regulator. Inactivating ptnR1 afforded S. platensis MA7339 mutant strain SB12600 that overproduces 2 at a titer approximately 100-fold greater than that from the wild-type strain and accumulates platencin A(1) (3) and eight new congeners, platencins A(2)-A(9) (4-11). The isolation, str ...[more]