Analysis of Recombinant CD24 Glycans by MALDI-TOF-MS Reveals Prevalence of Sialyl-T Antigen.
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ABSTRACT:
SUBMITTER: Motari E
PROVIDER: S-EPMC2856090 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Publications
Analysis of Recombinant CD24 Glycans by MALDI-TOF-MS Reveals Prevalence of Sialyl-T Antigen.
Motari Edwin E Zheng Xincheng X Su Xiaodan X Liu Yang Y Kvaratskhelia Mamuka M Freitas Michael M Wang Peng George PG
American journal of biomedical sciences 20090101 1
CD24 is a glycosyl-phosphatidyl-inositol linked glycoprotein expressed in a broad range of cell types and is heavily glycosylated. It has been found to be over expressed in cancers and tumors and is also a costimulatory molecule. Therefore, this study was carried out to define the structures of the carbohydrates associated with the CD24 recombinant protein. The CD24 glycoprotein's oligosaccharides were released by chemical and enzymatic means prior to being analyzed by MALDI-TOF-MS. The results ...[more]
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