Ontology highlight
ABSTRACT:
SUBMITTER: Vonlaufen N
PROVIDER: S-EPMC2856992 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Vonlaufen Nathalie N Naguleswaran Arunasalam A Coppens Isabelle I Sullivan William J WJ
The Journal of biological chemistry 20100216 15
The MYST family of lysine acetyltransferases (KATs) function in a wide variety of cellular operations, including gene regulation and the DNA damage response. Here we report the characterization of the second MYST family KAT in the protozoan parasite Toxoplasma gondii (TgMYST-B). Toxoplasma causes birth defects and is an opportunistic pathogen in the immunocompromised, the latter due to its ability to convert into a latent cyst (bradyzoite). We demonstrate that TgMYST-B can gain access to the par ...[more]