Ontology highlight
ABSTRACT:
SUBMITTER: Buttar NS
PROVIDER: S-EPMC2857022 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Buttar Navtej S NS DeMars Cathrine J CJ Lomberk Gwen G Ilyas Sumera I SI Bonilla-Velez Juliana J Achra Shalini S Rashtak Shahrooz S Wang Kenneth K KK Fernandez-Zapico Martin E ME Urrutia Raul R
The Journal of biological chemistry 20100212 15
Kruppel-like factor (KLF) proteins are emerging as key regulators of lipid metabolism, diabetes, and the biosynthesis of immunological cytokines. However, their role in the synthesis of prostaglandins, widely known biochemical mediators that act in a myriad of cell biological processes remain poorly understood. Consequently, in this study a comprehensive investigation at the cellular, biochemical, and molecular levels reveal that KLF11 inhibits prostaglandin E(2) synthesis via transcriptional si ...[more]