Ontology highlight
ABSTRACT:
SUBMITTER: Bayot A
PROVIDER: S-EPMC2857023 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Bayot Aurélien A Gareil Monique M Rogowska-Wrzesinska Adelina A Roepstorff Peter P Friguet Bertrand B Bulteau Anne-Laure AL
The Journal of biological chemistry 20100211 15
ATP-dependent proteases are currently emerging as key regulators of mitochondrial functions. Among these proteolytic systems, Pim1, a Lon-like serine protease in Saccharomyces cerevisiae, is involved in the control of selective protein turnover in the mitochondrial matrix. In the absence of Pim1, yeast cells have been shown to accumulate electron-dense inclusion bodies in the matrix space, to lose integrity of mitochondrial genome, and to be respiration-deficient. Because of the severity of phen ...[more]