Ontology highlight
ABSTRACT:
SUBMITTER: Hu D
PROVIDER: S-EPMC2857416 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Developmental dynamics : an official publication of the American Association of Anatomists 20081201 12
Bone morphogenetic proteins (BMPs) regulate many aspects of development including skeletogenesis. Here, we examined the response of neural crest-derived cells to ectopic BMP signaling by infecting avian embryos with retroviruses encoding Bmp-2 or Bmp-4 at various times of development. Infection at stages 10 and 15 transformed large areas of the skull into cartilage by day 13. At this time cartilage condensations were still forming, which revealed the presence of uncommitted mesenchymal cells. By ...[more]