Ontology highlight
ABSTRACT:
SUBMITTER: Matsumoto S
PROVIDER: S-EPMC2857468 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Matsumoto Shinji S Fumoto Katsumi K Okamoto Tetsuji T Kaibuchi Kozo K Kikuchi Akira A
The EMBO journal 20100311 7
Wnt5a is a representative ligand that activates the Wnt/beta-catenin-independent pathway, resulting in the regulation of cell adhesion, migration, and polarity, but its molecular mechanism is poorly understood. This report shows that Dishevelled (Dvl) binds to adenomatous polyposis coli (APC) gene product, and this binding is enhanced by Wnt5a. Dvl was involved in the stabilization of the plus end dynamics of microtubules as well as APC. Frizzled2 (Fz2) was present with Wnt5a at the leading edge ...[more]