Ontology highlight
ABSTRACT:
SUBMITTER: Yue J
PROVIDER: S-EPMC4261153 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Yue Jiping J Xie Min M Gou Xuewen X Lee Philbert P Schneider Michael D MD Wu Xiaoyang X
Developmental cell 20141201 5
Disassembly of focal adhesions (FAs) allows cell retraction and integrin detachment from the extracellular matrix, processes critical for cell movement. Growth of microtubules (MTs) can promote FA turnover by serving as tracks to deliver proteins essential for FA disassembly. The molecular nature of this FA "disassembly factor," however, remains elusive. By quantitative proteomics, we identified mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) as an FA regulator that associates w ...[more]