Ontology highlight
ABSTRACT:
SUBMITTER: Mangsbo SM
PROVIDER: S-EPMC2857538 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Mangsbo Sara M SM Sanchez Javier J Anger Kerstin K Lambris John D JD Ekdahl Kristina Nilsson KN Loskog Angelica S AS Nilsson Bo B Tötterman Thomas H TH
Journal of immunology (Baltimore, Md. : 1950) 20091028 10
Phosphorothioate oligodeoxynucleotides can activate complement, and experimental murine studies have revealed differential effects upon simultaneous TLR stimulation and complement activation compared with either event alone. We set out to investigate the immune stimulatory effects of CpG 2006 in fresh non-anticoagulated human blood with or without presence of active complement. We also sought to elucidate the mechanism behind complement activation upon stimulation with phosphorothioate CpG 2006. ...[more]