Ontology highlight
ABSTRACT:
SUBMITTER: Ichinohe T
PROVIDER: S-EPMC2857582 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Ichinohe Takeshi T Pang Iris K IK Iwasaki Akiko A
Nature immunology 20100411 5
Influenza virus, a negative-stranded RNA virus that causes severe illness in humans and animals, stimulates the inflammasome through the Nod-like receptor NLRP3. However, the mechanism by which influenza virus activates the NLRP3 inflammasome is unknown. Here we show that the influenza virus M2 protein, a proton-selective ion channel important in viral pathogenesis, stimulates the NLRP3 inflammasome pathway. M2 channel activity was required for the activation of inflammasomes by influenza and wa ...[more]